evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation

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Evaluation of eco-friendly zwitterionic detergents for ...- evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation ,Nov 09, 2016·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Lynn Conley Process Biochemistry, Biogen, 5000 Davis Drive, Research Triangle Park …METHODS FOR VIRAL INACTIVATION USING ECO-FRIENDLY DETERGENTSCriteria for alternative detergents included but were not limited to any one of non-ionic or zwitterionic nature of detergent, disposability, robust virus inactivation, cost, safety/OSHA, solubility, viscosity, hydrophile/lipophile balance of ˜12-15, material availability and source, impact to process and product quality, and stability of raw ...



Triton X-100 - Wikipedia

Triton X-100 is a commonly used detergent in laboratories. Triton X-100 is widely used to lyse cells to extract protein or organelles, or to permeabilize the membranes of living cells. Some applications include: Inactivation of lipid-enveloped viruses (e.g. HIV, HBV, HCV) in manufacturing of biopharmaceuticals.

Replication and transmission mechanisms of highly ...

Mar 16, 2020·CONLEY L , TAO Y , HENRY A et al. Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation[J]. Biotechnol Bioeng, 2017, 114 (4): 813- 820 doi: 10.1002/bit.26209 [1]

Virus inactivation by solvent/detergent treatment using ...

Sep 01, 2008·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, Ghose S. Biotechnol Bioeng, 114(4):813-820, 09 Nov 2016 Cited by: 3 articles | PMID: 27800626

Sanchayita GHOSE | PhD, Chemical & Biological Engineering ...

Viral surrogates to screen for virus inactivation (VI) can be a faster, cheaper and safer alternative to third-party testing of pathogenic BSL2 (Biosafety Level 2) model viruses.

Methods and compositions for inactivating enveloped viruses

Dec 06, 2018·Conley et al., Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Biotechnol Bioeng. Apr. 2017;114(4):813-820. doi: 10.1002/bit.26209. Epub Nov. 9, 2016. Cuatrecasas, P., Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation ...

Evaluation of eco-friendly zwitterionic detergents for ...

Request PDF | Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation | Inclusion of a detergent in protein biotherapeutic purification processes is a simple and very ...

Systematic assessment of SARS-CoV-2 virus in wastewater ...

Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation Nov 2, 2016 · Biotechnology and Bioengineering · Lynn Conley Sanchayita Ghose Fomite-mediated transmission as a sufficient pathway: a comparative analysis across three viral pathogens

Development of a Triton X‐100 replacement for effective ...

Dec 12, 2019·1 INTRODUCTION. In response to the transmission of viruses through plasma derivatives in the early 1980s, the solvent-detergent (S/D) treatment was developed to inactivate lipid-enveloped viruses, 1 and this technology is the most effective and robust method used for this purpose to date. 2 Over the three decades of use, mixtures of the solvent tri-n-butyl phosphate (TNBP) with detergents …

Impact of COVID-19 On Contact Lens Wear - mivision

Oct 15, 2021·5. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, et al. Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Biotechnol Bioeng. 2017;114(4):813-20. 6. Kampf G. Efficacy of ethanol against viruses in hand disinfection. J Hosp Infect. 2018;98(4):331-8. 7.

三种人类高致病性冠状病毒的增殖和传播机制研究进展

Mar 16, 2020·CONLEY L , TAO Y , HENRY A et al. Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation[J]. Biotechnol Bioeng, 2017, 114 (4): 813- 820 doi: 10.1002/bit.26209 [1]

Triton X-100 - WikiMili, The Best Wikipedia Reader

Triton X-100 (C 14 H 22 O(C 2 H 4 O) n) is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group. The hydrocarbon group is a 4-(1,1,3,3-tetramethylbutyl)-phenyl group.Triton X-100 is closely related to IGEPAL CA-630 or former Nonidet P-40, which might differ from it mainly ...

Dual Sourcing of Protein A Resin to Mitigate Supply Chain ...

Jun 20, 2018·Biogen has relied on a single supplier for protein A resin. To reduce the inherent risk of reliance on a single vendor for this critical material and mitigate potential interruption of drug-substance supply, they worked to identify a second protein A resin that …

Enveloped virus inactivation using neutral arginine ...

Nov 11, 2013·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, Ghose S. Biotechnol Bioeng, 114(4):813-820, 09 Nov 2016 Cited by: 2 articles | PMID: 27800626

Enveloped virus inactivation using neutral arginine ...

Nov 11, 2013·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, Ghose S. Biotechnol Bioeng, 114(4):813-820, 09 Nov 2016 Cited by: 2 articles | PMID: 27800626

Systematic assessment of SARS-CoV-2 virus in wastewater ...

Furthermore, when outside the host, enveloped viruses exhibit shorter lifespans (Firquet et al., 2015). Thenceforth, the shorter survival time for enveloped viruses is dictated by the proteolytic enzymes and effects of detergents on the external lipid envelope of the virus (Conley et al., 2017; Amoah et al., 2020).

Insights into virus inactivation by polysorbate 80 in the ...

Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Lynn Conley, Yinying Tao, Alexis Henry, Edward Koepf, Douglas Cecchini, John Pieracci, Sanchayita Ghose Biotechnology and Bioengineering 2017, 114 (4): 813-820

Virus inactivation in a factor VIII/VWF concentrate ...

Oct 10, 2008·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, Ghose S. Biotechnol Bioeng, 114(4):813-820, 09 Nov 2016 Cited by: 7 articles | PMID: 27800626

Sanchayita GHOSE | PhD, Chemical & Biological Engineering ...

Viral surrogates to screen for virus inactivation (VI) can be a faster, cheaper and safer alternative to third-party testing of pathogenic BSL2 (Biosafety Level 2) model viruses.

Synthesis of “Nereid,” a new phenol‐free detergent to ...

Dec 04, 2020·In the 1980s, virus inactivation steps were implemented into the manufacturing of biopharmaceuticals in response to earlier unforeseen virus transmissions. The most effective inactivation process for lipid-enveloped viruses is the treatment by a combination of detergents, often including Triton X-100 (TX-100).

Methods and compositions for inactivating enveloped viruses

Dec 06, 2018·Conley et al., Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Biotechnol Bioeng. Apr. 2017;114(4):813-820. doi: 10.1002/bit.26209. Epub Nov. 9, 2016. Cuatrecasas, P., Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation ...

Novel Virus Clearance and Virus Detection Technologies …

Dec 03, 2018·• LDAO – Biogen Eco Friendly Zwitterionic (Amphoteric) Detergent . Conley, L. et al., Biotechnol and Bioeng 2017 114(4):813-820. TRITON X-100. TRITON CG-110. Triton . CG-110 – Genentech/Roche Non-ionic Eco-friendly Detergent. 3. X-MuLVinactivation in HCCF at 12 °C 1 hour Inactivation of other enveloped viruses HCCF, 0.3%, 1 hour, 20. o. C

NON-IONIC—CATIONIC MICELLAR PROPERTIES OF ...

Structure of the detergent phase and protein-detergent interactions in crystals of the wild-type (strain Y) Rhodobacter sphaeroides photochemical reaction center. ... Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Biotechnology and Bioengineering 2017, 114 (4) ...

[PDF] Maturation of the Gag core decreases the stability ...

To better understand how detergents disrupt enveloped viruses, we monitored the biophysical stability of murine leukemia virus (MLV) virus-like particles (VLPs) against a panel of commonly used detergents using real-time biosensor measurements. Although exposure to many detergents, such as Triton X-100 and Empigen, results in lysis of VLP membranes, VLPs appeared resistant to complete …

‪Sanchayita Ghose‬ - ‪Google Scholar‬

Evaluation of eco‐friendly zwitterionic detergents for enveloped virus inactivation L Conley, Y Tao, A Henry, E Koepf, D Cecchini, J Pieracci, S Ghose Biotechnology and bioengineering 114 …

Virus inactivation in a factor VIII/VWF concentrate ...

Oct 10, 2008·Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Conley L, Tao Y, Henry A, Koepf E, Cecchini D, Pieracci J, Ghose S. Biotechnol Bioeng, 114(4):813-820, 09 Nov 2016 Cited by: 7 articles | PMID: 27800626

Insights into virus inactivation by polysorbate 80 in the ...

Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Lynn Conley, Yinying Tao, Alexis Henry, Edward Koepf, Douglas Cecchini, John Pieracci, Sanchayita Ghose Biotechnology and Bioengineering 2017, 114 (4): 813-820